Xylazine: Usage, Restrictions, and Controlled Substance Classification

Posted By : Rph Buddy

Introduction: ‘

Xylazine is a medication primarily used in veterinary medicine as a sedative, analgesic, and muscle relaxant for animals. While it is not approved for human use in most countries, including the United States, Xylazine has gained attention due to its misuse as a recreational drug. In this article, we will explore the usage, restrictions, and controlled substance classification of Xylazine in the United States.


Usage of Xylazine:

Xylazine, also known by its brand name Rompun®, is commonly used by veterinarians to sedate animals, particularly horses and cattle, for various procedures. It acts as a sedative, providing calming effects, and can also provide pain relief and muscle relaxation. Xylazine works by acting on the central nervous system, specifically targeting receptors in the brain.

Restrictions on Human Use:

In the United States, Xylazine is not approved by the Food and Drug Administration (FDA) for human use. This means that it is illegal to use Xylazine in humans except under specific circumstances, such as clinical trials or emergency situations where no other suitable medications are available. The use of Xylazine in humans is generally considered off-label and carries potential health risks.

Recreational Use and Misuse:

Despite its lack of approval for human use, Xylazine has been misused as a recreational drug in some instances. It is sometimes combined with opioids, such as heroin or fentanyl, to enhance the effects or stretch the drug supply. The combination of Xylazine and opioids can be particularly dangerous, leading to increased sedation, respiratory depression, and overdose risks. The recreational use of Xylazine poses significant health risks and is illegal.

Controlled Substance Classification:

In the United States, the Drug Enforcement Administration (DEA) classifies drugs into different schedules based on their potential for abuse, medical use, and safety profiles. Xylazine is classified as a controlled substance under Schedule IV of the Controlled Substances Act (CSA). Schedule IV substances have a lower potential for abuse compared to drugs in Schedules I, II, and III, and they have an accepted medical use with limited dependence or addiction potential.

As a Schedule IV controlled substance, Xylazine is subject to certain regulations and restrictions. These include stricter controls on its manufacturing, distribution, prescription, and possession. Healthcare professionals, such as veterinarians, must adhere to specific guidelines when handling and prescribing Xylazine to ensure its proper use and prevent misuse or diversion.


Xylazine is primarily used as a veterinary medication for sedation, pain relief, and muscle relaxation in animals. While it is not approved for human use in the United States, it has gained attention due to its misuse as a recreational drug. Xylazine is classified as a Schedule IV controlled substance, indicating its potential for abuse and limited dependence liability. Misusing Xylazine or combining it with other substances can be extremely dangerous and is illegal. It is crucial to adhere to the regulations and restrictions in place to ensure the safe and appropriate use of Xylazine in veterinary practice.

Disclaimer: This article is for informational purposes only and should not be considered medical or legal advice. For accurate and up-to-date information on Xylazine, its usage, restrictions, and controlled substance classification, consult medical professionals and regulatory authorities in your jurisdiction.

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